| Date | Location | Result | |
| 03/07/22 | Sioux Falls, S.D. (PREMIER Center) | South Dakota St. 83, South Dakota 60 | Box score |
| 03/06/22 | Sioux Falls, S.D. (PREMIER Center) | South Dakota 74, Kansas City 61 | Box score |
| 02/26/22 | Tulsa, Okla. (Mabee Center) | South Dakota 92, Oral Roberts 87 | Box score |
| 02/24/22 | Kansas City, Mo. (Swinney Center) | Kansas City 72, South Dakota 63 | Box score |
| 02/19/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 78, Western Ill. 65 | Box score |
| 02/17/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 81, St. Thomas (MN) 60 | Box score |
| 02/12/22 | Denver, Colo. (Hamilton Gymnasium) | South Dakota 84, Denver 76 | Box score |
| 02/10/22 | Omaha, Neb. (Baxter Arena) | South Dakota 91, Omaha 69 | Box score |
| 02/07/22 | Fargo, N.D. (Scheels Arena) | North Dakota St. 76, South Dakota 74 | Box score |
| 02/05/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota St. 89, South Dakota 79 | Box score |
| 01/29/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 71, North Dakota 58 | Box score |
| 01/27/22 | Vermillion, S.D. (Sanford Coyote SC) | North Dakota St. 74, South Dakota 62 (OT) | Box score |
| 01/24/22 | Macomb, Ill. (Western Hall) | South Dakota 75, Western Ill. 72 | Box score |
| 01/22/22 | Saint Paul, Minn. (Schoenecker Arena) | South Dakota 90, St. Thomas (MN) 79 | Box score |
| 01/15/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 105, Omaha 70 | Box score |
| 01/13/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 80, Denver 71 | Box score |
| 01/10/22 | Grand Forks, N.D. (The Betty) | South Dakota 75, North Dakota 68 | Box score |
| 01/08/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 84, South Dakota 65 | Box score |
| 12/22/21 | Vermillion, S.D. (Sanford Coyote SC) | Kansas City 68, South Dakota 57 | Box score |
| 12/20/21 | Vermillion, S.D. (Sanford Coyote SC) | Oral Roberts 82, South Dakota 73 | Box score |
| 12/15/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 78, Bellarmine 64 | Box score |
| 12/11/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 76, Northern Ariz. 71 (OT) | Box score |
| 12/07/21 | Greeley, Colo. (Colorado Arena) | Northern Colo. 74, South Dakota 69 | Box score |
| 12/03/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 93, Waldorf 37 | Box score |
| 11/30/21 | San Jose, Calif. (Event Center Arena) | San Jose St. 61, South Dakota 52 | Box score |
| 11/27/21 | Lincoln, Neb. (Pinnacle Bank Arena) | Nebraska 83, South Dakota 70 | Box score |
| 11/23/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 99, Presentation 58 | Box score |
| 11/21/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 83, Tennessee St. 66 | Box score |
| 11/19/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 71, Southern U. 68 | Box score |
| 11/14/21 | Des Moines, Iowa (Knapp Center) | Drake 99, South Dakota 50 | Box score |
| 11/11/21 | Sioux Falls, S.D. (Sanford Pentagon) | South Dakota 59, Air Force 53 | Box score |